Research

The Geração 21 project is developed by the Faculdade de Medicina (FMUP) and the Instituto de Saúde Pública (ISPUP) da Universidade do Porto and is the first population-based birth cohort in Portugal. Besides the several specific objectives, Geração 21 focuses on the study of fetal and childhood determinants in the development of obesity and bodily composition.
Projects
EXALAR 21: The influence of exposure to urban air pollutants, green and blue spaces, and biodiversity on the development of allergic diseases and asthma in children (POCI-01-0145-FEDER-030193)  
01.06.2018 - 31.05.2021
Appetite and obesity: Regulação do apetite e obesidade infantil: uma abordagem para compreender as influências genéticas e comportamentais (POCI-01-0145-FEDER-030334)
01.06.2018 - 31.05.2021
FOCAcCia: Exposure to food additives and contaminants from food processing and packaging: Defining patterns and their effects on adiposity and cognitive function from childhood to adolescence (POCI-01-0145-FEDER-031949)
01.07.2018 - 30.06.2021
STEPACHE - The pediatric roots of amplified pain: from contextual influences to risk stratification (POCI-01-0145-FEDER-029087)
16.07.2018 - 15.07.2021
HIneC “When do health inequalities start? Understanding the impact of childhood social adversity on health trajectories from birth to early adolescence (POCI-01-0145-FEDER—029567)
16.07.2018 - 15.07.2021
LIFEPATH - Lifecourse biological pathways underlying social differences in healthy ageing
01.04.2015 - 30.04.2019
BioAdversity – How social adversity in childhood influence health: the biology of social adversity
16.05.2016 - 16.05.2019
Cardiovascular risks factors for mothers and children 3 years after delivery 
Geração XXI - follow-up at 4 years of age
01.04.2009 - 31.12.2011
Generation XXI – Nascer e crescer no início do Milénio
28.12.2004 - 30.06.2007
Early development of obesity and the metabolic syndrome
01.04.2010 - 30.09.2013
Eating habits in preschool children: a longitudinal approach to the identification of determinants and effects on body composition
01.04.2010 - 30.06.2013
Understanding the dynamics of childhood body fat - the mediating effect of dietary patterns and eating behaviors
01.05.2013 - 15.10.2015
Violence in various stages of life: frequency, determinants and consequences of health
06.05.2012 - 30.10.2015
PathMOB: Pathways from early life to cardiometabolic risk during childhood (POCI-01-0145-FEDER-016837)
15.05.2016 - 15.05.2019
HabEat - Determining factors and critical periods in food habit formation and breaking in early childhood: a multidisciplinary approach
01.01.2010 - 31.12.2013
Publications
Household Dysfunction Is Associated With Bullying Behavior in 10-year-old Children: Do Socioeconomic Circumstances Matter?

Fraga, S.; Soares, S.; Soares Peres, F.; Barros, H.

Journal of Interpersonal Violence, 2021. doi: 10.1177/08862605211006352

Serum Levels of Vitamin D and Dental Caries in 7-Year-Old Children in Porto Metropolitan Area.

Carvalho Silva C, Gavinha S, Manso MC, Rodrigues R, Martins S, Guimarães JT, Santos AC, Melo P.

Nutrients, 2021 Jan 7;13(1):E166. doi: 10.3390/nu13010166.

Higher diversity of vegetable consumption is associated with less airway inflammation and prevalence of asthma in school-aged children.

Mendes F, Paciência I, Cavaleiro Rufo J, Farraia M, Silva D, Padrão P, Delgado L, Garcia-Larsen V, Moreira A, Moreira P.

Pediatr Allergy Immunol, 2021 Jan 4. doi: 10.1111/pai.13446. Online ahead of print.

Parents' use of extreme physical violence is associated with elevated high-sensitivity C-reactive protein in children.

Fraga S, Soares S, Santos AC, Barros H.

J Affect Disord, 2020 Dec 30;282:454-457. doi: 10.1016/j.jad.2020.12.154. Online ahead of print.

Adiposity rebound and cardiometabolic health in childhood: results from the Generation XXI birth cohort.

Fonseca MJ, Moreira C, Santos AC.

Int J Epidemiol, 2021 Feb 1;dyab002. doi: 10.1093/ije/dyab002. Online ahead of print.

Neighbourhood green and blue spaces and allergic sensitization in children: a longitudinal study based on repeated measures from the Generation XXI cohort.

Paciência I, Moreira A, Moreira C, Cavaleiro Rufo J, Sokhatsk O, Rama T, Hoffimann E, Santos AC, Barros H, Ribeiro AI.

Science of The Total Environment, 2021, 145394, ISSN 0048-9697, https://doi.org/10.1016/j.scitotenv.2021.145394.

History of work-related health problems in a population-based sample of women: An exploratory factor analysis.

Amaro J, Ubalde-López M, Lucas R.

Work, 2021 Feb 16. doi: 10.3233/WOR-203394. Online ahead of print.

Use of a hybrid method to derive dietary patterns in 7 years olds with explanatory ability of body mass index at age 10.

Pinto A, Severo M, Oliveira A.

Eur J Clin Nutr, 2021 Mar 5. doi: 10.1038/s41430-021-00883-9. Online ahead of print.

Psychosocial stress in pregnancy: determinants and consequences for mother and baby.

Fraga, S.; Soares, S.; Barros, H.

Proceedings of the Brazilian Congress of Epidemiology (ISSN: 2594-6293). Florianópolis, Brazil; Vol 1, 2017 – 76684; doi: 10.17648/epi-2017

Violence in childhood and its relationship with inflammation and DNA methylation processes

Soares, S.; Rocha, V.; Fraga, S.

Proceedings of the Brazilian Congress of Epidemiology (ISSN: 2594-6293). Florianópolis, Brazil; Vol 1, 2017 – 76685; doi: 10.17648/epi-2017

Socioeconomic status and C-Reactive protein in childhood.

Fraga, S.; Soares, S.; Santos, A.C.; Barros, H.

X Congresso Brasileiro de Epidemiologia; In: Anais do Congresso Brasileiro de Epidemiologia (ISSN: 2594-6293). Florianópolis, Brazil; Vol 1, 2017 – 74147; doi: 10.17648/epi-2017

Association of maternal exposure to violence with breasfeeding practices.

Rodrigues, C.; Soares, S.; Fraga, S.; Barros, H.

XXXVI Reunión Científica de la Sociedad Española de Epidemiología y XIII Congresso da Associação Portuguesa de Epidemiologia; In: Gaceta Sanitaria. Lisbon, Portugal; Vol 32 (Espec Cong); 7-140. 2018.

Prevalence of bullying involvement in 10 year-old children: a study in Geração XXI.

Soares, S.; Santos, A.C.; Barros, H.; Fraga, S.

XXXVI Reunión Científica de la Sociedad Española de Epidemiología y XIII Congresso da Associação Portuguesa de Epidemiologia; In: Gaceta Sanitaria. Lisbon, Portugal; Vol 32 (Espec Cong); 141-799. 2019

Early socioeconomic circumstances and adverse childhood experiences in 10-year-old children.

Soares Peres, F.; Soares, S.; Barros, H.; Santos, A.C.; Fraga, S.

European Journal of Public Health, Volume 29, Issue Supplement_4, November 2019, ckz187.186, https://doi.org/10.1093/eurpub/ckz187.186

Early socioeconomic circumstances and cardiometabolic health in 10-year-old children.

Soares, S.; Santos, A.C.; Soares Peres, F.; Barros, H.; Fraga S.

European Journal of Public Health, Volume 29, Issue Supplement_4, November 2019, ckz187.185, https://doi.org/10.1093/eurpub/ckz187.185

Effect of problematic eating behaviors on the quality of food at 7 years of age.  

Pinto A, Costa S, Lopes C, Oliveira A.

Acta Portuguesa de Nutrição (APN) 2016; 40-41.

Inflammation grade, Parental Violence and Socioeconomic Position: The evidence from biological consequences of social adversity in childhood.

Soares, S.

Young Researchers Forum; 9th European Public Health Conference; 9th-12th November 2016; Vienna, Austria )3rd award in oral presentation at the Young Researchers Forum from ASPHER, 10th November 2016)

Biologia da adversidade social: Como a adversidade na infância condiciona a saúde.

Fraga, S.; Soares, S.

Encontro Ciência’17; 3-5 July, 2017; Lisbon, Portugal

Association of maternal exposure to violence with breasfeeding practices.

Rodrigues, C.; Soares, S.; Fraga, S.; Barros, H.

XXXVI Reunión Científica de la Sociedad Española de Epidemiología y XIII Congresso da Associação Portuguesa de Epidemiologia; 12-14 September, 2018; Lisbon, Portugal

Social determinants and health inequalities.

Soares, S.; Fraga S.

Public Session of Clarification; 23rd May 2017; ISPUP, Porto, Portugal

Involvement in fights, bullying and cyberbullying.

Soares, Sara.

World Mental Health Day; 10th October 2018; Porto, Portugal

Violence on children in the family and at school.

Soares, Sara.

Family and Violence Seminar, organized by Associação Mulher Século XXI; 30th November 2018; Escola Superior de Saúde de Leiria, Leiria, Portugal

Involvement in fights, bullying and cyberbullying.

Soares, Sara.

Week of affections; Awareness public presentation to students from public schools; 13th February 2019; Agrupamento de Escolas Fontes Pereira de Melo, Porto, Portugal

Socio-demographic associates of children's perception of food insecurity in a Portuguese population-based birth cohort.

Maia I, Severo M, Santos AC.

ASPHER Young Researchers Forum. Lublijana, Slovenia (Nov, 2018).

Consequences of stressful life events during pregnancy: a Generation XXI cohort study.

Fraga, S.; Soares, S.; Santos, A.C.; Barros, H.

21st International Epidemiological Association (IEA), World Congress of Epidemiology (WCE2017); 19th-22nd August 2017; Sonic City, Saitama, Japan

Psychosocial stress in pregnancy: determinants and consequences for mother and baby.

Fraga, S.; Soares, S.; Barros, H.

X Brazilian Congress of Epidemiology. 7-11 October, 2017; Florianópolis, Brazil

Violence in childhood and its relationship with inflammation and DNA methylation processes.

Soares, S.; Rocha, V., Fraga, S.

X Brazilian Congress of Epidemiology. 7-11 October, 2017; Florianópolis, Brazil

The influence of Children’s Eating Behaviours related to appetite on adherence to a healthy diet at 7 years of age.

Costa MP, Oliveira A, Lopes C, Vilela S.

XVII Congress of Nutrition and Food and I International Congress of Nutrition and Food. Lisbon, Portugal, 10-11 May, 2018.

The influence of children’s eating behaviours related to appetite on adherence to a healthy diet at 7 years of age.

Marta Pinto da Costa, Andreia Oliveira, Carla Lopes, Sofia Vilela. T

XVII Congresso de Alimentação e Nutrição/I International Congress of Food and Nutrituion from APN. Lisbon, 10-11 May, 2018.

The interaction effect of individual and neighbourhood socioeconomic conditions on all-cause mortality – a multi-cohort analysis.

Ribeiro, Ana Isabel; Fraga, Silvia; Kelly-Irving, Michelle; Delpierre, Cyrille; Kivimaki, Mika; Joost, Stéphane; Guessous, Idris; et al. 2019.

Paper presented in Lifepath Annual Meeting 2019.

Associations of appetitive behaviors at 7 years old with cardiometabolic health at 10 years old children from the Geração XXI birth cohort.

Warkentin S, Santos AC, Oliveira A.

18th meeting of the International Society of Behavioral Nutrition and Physical Activity (ISBNPA). Praga, República Tcheca, 4-7 de Junho, 2019.

Relationship between time-of-day energy and macronutrient intake and children’s body weight status: a prospective meal-timing analysis.

Vilela S, Oliveira A, Severo M, Lopes C.

26th European Congress on Obesity. Glasgow, Scotland, 28th April-1st May, 2019.

Biological consequences of exposure to social adversity in childhood.

Soares, Sara.

Doctoral Programme in Public Health, University of Porto. 2020.

 

Person, place and time contexts of growth and development of second generation migrant children in Portugal

Kana, Musa.

Doctoral Programme in Public Health, University of Porto. 2018.

Fetal Growth and Dietary Intake During Pregnancy: Results of Porto Birth Cohort

Pinto, Elisabete.

Doctoral Programme in Public Health, University of Porto. 2010.

Cardiovascular Risk Profile in Mothers of a Portuguese Birth Cohort

Alves, Elisabete.

Doctoral Programme in Public Health, University of Porto. 2012.

Cesarean - a role for culture, society and health care

Teixeira, Cristina.

Doctoral Programme in Public Health, University of Porto. 2013.

Prevalence and incidence of Helicobacter pylori infection in three Portuguese cohorts

Bastos, Joana Antunes de Lima.

Doctoral Programme in Public Health, University of Porto. 2013.

Reproductive and perinatal health in Portugal: social circumstances at the micro and macro level

Correia, Sofia.

Doctoral Programme in Public Health, University of Porto. 2014.

A influência dos determinantes de cárie dentária na prevalência da doença em crianças do Grande Porto

Coelho, Carina

Doctoral Programme in Dental Medicine, University of Porto. A decorrer

Association of early socioeconomic circumstances with lung function in children: a study in the Generation XXI cohort.

Toluhi, K.

  • Master Thesis in Public Health. University of Porto. Ongoing.
Determinants of the evolution of nocturnal enuresis in children between 4 and 7 years old (Provisional title).

Morais, J.

Master Thesis in Medicine. Faculty of Medicine of the University of Porto. Ongoing.

The effect of sleeping habits and problems at 4 and 7 year of age on cardiometabolic health.

Guedes, Raissa.

Master Degree in Public Health. University of Porto. 2020.

Long and short term complications of hypertensive disorders of pregnancy.

Yusuf, Bilkisu.

Master Degree Course in Public Health. University of Porto. 2020.

Weight, appetitive behaviours and parental feeding practices in childhood: their association and reciprocal influences.

Costa, Alexandra.

Master Degree Course in Public Health. University of Porto. 2020.

Influence of parental child-feeding practices on dietary patterns of 7 year-old from Generation XXI.

Barbosa, Catarina.

Master Degree Course in Public Health. University of Porto. 2020.

The effect of sugar-sweetened beverages on children’s appetitive behaviours: a prospective approach from the Generation XXI birth cohort

Costa, Daniela.

Mastr in Public Health. University of Porto. 2019.

Healthy eating patterns in childhood: tracking and its related factors  

Costa, Marta.

Master in Public Health. University of Porto. 2019.

Awards and prizes
How does early socioeconomic circumstances impact inflammatory trajectories? Findings from Generation XXI.

Soares, S.; López-Chéda, A.; Santos, A.C.; Barros, H.; Fraga, S.

Programa IACOBUS - Publicacións Científicas (Papers), 2021. Psychoneuroendocrinology, doi: https://doi.org/10.1016/j.psyneuen.2020.104755)

Inflammation grade, Parental Violence and Socioeconomic Position: The evidence from biological consequences of social adversity in childhood.

Sara Soares.

3rd award in oral presentation at the Young Researchers Forum from ASPHER, 10th November 2016. Young Researchers Forum; 9th European Public Health Conference; 9th-12th November 2016; Vienna, Austria)

Young Nutritionist Merit Award - Honorable Mention Award.

Ana Sofia Vilela.

Order of Nutritionists (Portugal). 

1st Award Best Comunicattion in Poster.

Andreia Vaz et al.

XVIII Congress of Nutrition and Food (Portugal). 

Santander Universidades Idea Puzzle®

Sara Soares.

Santarder Totta Bank. 

ESCEO-Ag Novos Healthcare Young Investigation Award.

Teresa Monjardino.

World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases 2017.

Identification of dietary patterns at 7 years-old that explain body mass index (BMI) at 10 years-old: comparison of 3 methodological approaches in the G21 cohort.

Andreia Pinto, Andreia Oliveira. 

3rd Prize of best oral communication. XVII Congress of Food and Nutrition/I International Congress of Food and Nutrition. Lisbon, 10-11 May, 2018. 

Early Career Investigator for September issue of Pediatric Research.

Raquel Lucas.

Pediatric Research. 

Best Publication (Edition 2017).

Catarina Durão.

Portuguese Association of Epidemiology.

Sexo e obesidade modificam o impacto do sal na pressão arterial em crianças

Costa L, Cosme D, Nogueira-Silva L, Morato M, Sousa T, Moura C, Mota C, Guerra A, Albino-Teixeira A, Areias JC, Schaefer F, Lopes C, Caldas-Afonso A, Azevedo A.

Oral communication. Best work in other pediatric áreas. Pfizer Vacinas-SPP. 16º Congresso Nacional de Pediatria. Albufeira October 2015.

Social Trajectory and Body Image Satisfaction in Childbearing Women

Henriques A, Alves L, Alves E, Silva S, Barros H, Azevedo A.

Maternal and Child Health Journal. 2015 Jun;19(6):1237-44. Best 2014 publication, Associação Portuguesa de Epidemiologia. August 2015.

Dietary patterns at 4 years of age: are they associated with appetite-related eating behaviours in 7 year-old children?

Albuquerque G, Lopes c, Durão C, Severo M, Moreira P, Oliveira A.

II Ibero-American Congress of Epidemiology and Public Health. Santiago de Compostela, Spain, 2-4 September, 2015. 1st award “Patxi Català” SESPAS-EASP – best oral presentation.

Consumo alimentar e nutricional de crianças em idade pré-escolar: Resultados da coorte Geração 21

Carla Lopes, Andreia Oliveira, Lisa Afonso, Teresa Moreira, Catarina Durão, Milton Severo, Sofia Vilela, Elisabete Ramos, Henrique Barros

Instituto de Saúde Pública da Universidade do Porto 2014. (ISBN: 978-989-98867-4-2). 1st award Food & Nutrition Awards 2014 (APN/GCI) – research and development category.

Da mesa à horta: aprendo a gostar de fruta e vegetais: Um guia prático para pais e cuidadores de crianças em idade pré-escolar

Carla Lopes, Andreia Oliveira, Lisa Afonso, Catarina Durão, Pedro Moreira, Elisabete Pinto, Elisabete Ramos, Henrique Barros

Instituto de Saúde Pública da Universidade do Porto 2014. (ISBN: 978-989-98867-3-5). 2nd honorable mention, Food & Nutrition Awards 2014 (APN/GCI) – category mobilization initiative.

Identificação de padrões alimentares em crianças com 4 anos de idade

Durão C, Severo M, Oliveira A, Ramos E, Lopes C

Best oral presentation, XIII Congresso de Nutrição e Alimentação da Associação Portuguesa dos Nutricionistas. Porto, 22 May 2014.

Association between energy-dense food consumption at 2 years of age and diet quality at 4 years of age

Vilela S, Oliveira A, Ramos E, Moreira P, Barros H, Lopes C

Br J Nutr. 2014 Apr 14;111(7):1275-82. Best publication of 2013, Associação Portuguesa de Epidemiologia.

Association between energy-dense food consumption at 2 years of age and diet quality at 4 years of age

Vilela S, Oliveira A, Ramos E, Moreira P, Barros H, Lopes C.

Br J Nutr. 2013 Nov 14:1-8. DOI:http://dx.doi.org/10.1017/S0007114513003620. Associação Portuguesa de Epidemiologia, 2013. Best publication of research in epidemiology (population, clinical or translational)

Disciplina parental e saúde: um estudo na coorte Geração 21

Diogo Mendes, Isabel Moreira, Henrique Barros

3º Congresso sobre o Abuso e Negligência de Crianças. 2013. Porto, Portugal. Best oral presentation.

Perda de peso neonatal numa amostra portuguesa - coorte de nascimento Geração XXI

Maria João Fonseca, Milton Severo, Henrique Barros, Ana Cristina Santos

14º Congresso Nacional de Pediatria. 2013. Porto, Portugal. – Best work in general pediatrics.

 Early growth and the risk of childhood asthma: a meta-analysis of 1,000 European children

Sonnenschein-van der Voort AMM, Arends LR,  Jongste JC de, Annesi-Maesano I, Barros H, Basterrechea M, Bisgaard H, Chatzi L, Corpeleijn E, Correia S, Craig LC, et al.

European Respiratory Society Annual Meeting. 2013. Barcelona, Spain. Best Abstract in Paediatric Respiratory Epidemiology

Obesidade saudável em mulheres Portuguesas após a maternidade

Henriques A, Azevedo A, Barros H.

16º Congresso Português de Obesidade. Lisbon. November 2012. Best oral presentation in obesity and comorbidities.

Satisfação com a imagem corporal antes da gravidez e excesso de peso quatro anos após o parto

Henriques A, Alves E, Azevedo A, Barros H.

15º Congresso Português de Obesidade. Coimbra. November 2011. Best oral presentation in psychology.

Determinantes sociais do consumo de alimentos de elevada densidade energética em crianças de 2 anos

Sofia Vilela, Andreia Oliveira, Ana cristina Santos, Elisabete Pinto, Isabel Moreira, Carla Lopes

X Congresso de Nutrição e Alimentação & Congresso Ibero-Americano de Nutrição. 2011. Lisbon, Portugal. Best oral presentation.

Cigarette smoking cessation during pregnancy and sustainability 4 years after delivery

Alves E, Correia S, Azevedo A, Barros H.

Congresso Mundial de Epidemiologia. Edimburgo, 2011. Best panel presentation in “Global Problems”.

Prevalência e determinantes da infecção por helicobacter pylori no início da vida: resultados de uma coorte de nascimento portuguesa

Nuno Lunet

2011. Scientific Research award Dr.ª Maria Odette Ferreira-Santos.

Avaliação da ingestão alimentar em grávidas portuguesas

Elisabete Pinto, Carla Lopes, Milton Severo, Elisabete Ramos, Sofia Correia, Susana Cabral, Isabel dos Santos Silva, Henrique Barros

Nutrition Awards. 2011. Research Award in Nutrition Sciences.

Colaborations
Projects in collaboration with international institutions
Birthcohorts.net
CHICOS– Developing a Child Cohort Research Strategy for Europe
ENRIECO – Environmental Health Risks in European Birth Cohorts
EUCCONET – The European Child Cohort Network