Research

The Geração 21 project is developed by the Faculdade de Medicina (FMUP) and the Instituto de Saúde Pública (ISPUP) da Universidade do Porto and is the first population-based birth cohort in Portugal. Besides the several specific objectives, Geração 21 focuses on the study of fetal and childhood determinants in the development of obesity and bodily composition.
Projects
EXALAR 21: The influence of exposure to urban air pollutants, green and blue spaces, and biodiversity on the development of allergic diseases and asthma in children (POCI-01-0145-FEDER-030193)  
01.06.2018 - 31.05.2021
Appetite and obesity: Regulação do apetite e obesidade infantil: uma abordagem para compreender as influências genéticas e comportamentais (POCI-01-0145-FEDER-030334)
01.06.2018 - 31.05.2021
FOCAcCia: Exposure to food additives and contaminants from food processing and packaging: Defining patterns and their effects on adiposity and cognitive function from childhood to adolescence (POCI-01-0145-FEDER-031949)
01.07.2018 - 30.06.2021
STEPACHE - The pediatric roots of amplified pain: from contextual influences to risk stratification (POCI-01-0145-FEDER-029087)
16.07.2018 - 15.07.2021
HIneC “When do health inequalities start? Understanding the impact of childhood social adversity on health trajectories from birth to early adolescence (POCI-01-0145-FEDER—029567)
16.07.2018 - 15.07.2021
LIFEPATH - Lifecourse biological pathways underlying social differences in healthy ageing
01.04.2015 - 30.04.2019
BioAdversity – How social adversity in childhood influence health: the biology of social adversity
16.05.2016 - 16.05.2019
Cardiovascular risks factors for mothers and children 3 years after delivery 
Geração XXI - follow-up at 4 years of age
01.04.2009 - 31.12.2011
Generation XXI – Nascer e crescer no início do Milénio
28.12.2004 - 30.06.2007
Early development of obesity and the metabolic syndrome
01.04.2010 - 30.09.2013
Eating habits in preschool children: a longitudinal approach to the identification of determinants and effects on body composition
01.04.2010 - 30.06.2013
Understanding the dynamics of childhood body fat - the mediating effect of dietary patterns and eating behaviors
01.05.2013 - 15.10.2015
Violence in various stages of life: frequency, determinants and consequences of health
06.05.2012 - 30.10.2015
PathMOB: Pathways from early life to cardiometabolic risk during childhood (POCI-01-0145-FEDER-016837)
15.05.2016 - 15.05.2019
HabEat - Determining factors and critical periods in food habit formation and breaking in early childhood: a multidisciplinary approach
01.01.2010 - 31.12.2013
Publications
Association between eating frequency and eating behaviours related to appetite from 4 to 7 years of age: Findings from the population-based birth cohort generation XXI

Vilela S, Severo M, Moreira T, Oliveira A, Hetherington MM, Lopes C.

Appetite. 2019 Jan 1;132:82-90. doi: 10.1016/j.appet.2018.10.002. Epub 2018 Oct 5.

Chrono-Nutrition: The Relationship between Time-of-Day Energy and Macronutrient Intake and Children's Body Weight Status.  

Vilela S, Oliveira A, Severo M, Lopes C.

J Biol Rhythms. 2019 Mar 28:748730419838908. doi: 10.1177/0748730419838908. [Epub ahead of print].

Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts

Santos S, Voerman E, Amiano P, Barros H, Beilin LJ, Bergström A, Charles MA, Chatzi L, Chevrier C, Chrousos GP, Corpeleijn E, Costa O, Costet N, Crozier S, Devereux G, Doyon M, Eggesbø M, Fantini MP, Farchi S, Forastiere ,Santos AC,Standl M, Stigum H, Stoltenberg C, Thiering E, Thijs C, Torrent M, Tough SC, Trnovec T, Turner S, van Gelder M, van Rossem L, von Berg A, Vrijheid M, Vrijkotte T, West J, Wijga AH, Wright J, Zvinchuk O, Sørensen T, Lawlor DA, Gaillard R, Jaddoe V.

BJOG. 2019 Jul;126(8):984-995. doi: 10.1111/1471-0528.15661. Epub 2019 Mar 20.

Association between neighbourhood green space and biological markers in school-aged children. Findings from the Generation XXI birth cohort

Ribeiro AI, Tavares C, Guttentag A, Barros H.

Environ Int. 2019 Aug 3;132:105070. doi: 10.1016/j.envint.2019.105070. [Epub ahead of print]. 

Hotspots of childhood obesity in a large metropolitan area: does neighbourhood social and built environment play a part?

Ribeiro AI, Santos AC, Vieira VM, Barros H.

Int J Epidemiol. 2019 Oct 11. pii: dyz205. doi: 10.1093/ije/dyz205. [Epub ahead of print].

Dietary patterns at 7 year-old and their association with cardiometabolic health at 10 year-old

Pinto A, Santos AC, Lopes C, Oliveira A.

Clin Nutr. 2019 May 10. pii: S0261-5614(19)30218-3. doi: 10.1016/j.clnu.2019.05.007. [Epub ahead of print]. 

The contribution of sleep to social inequalities in cardiovascular disorders: a multi-cohort study

Petrovic D, Haba-Rubio J, de Mestral Vargas C, Kelly-Irving M, Vineis P, Kivimäki M, Nyberg S, Gandini M, Bochud M, Vollenweider P, d'Errico A, Barros H, Fraga S, Goldberg M, Zins M, Steptoe A, Delpierre C, Heinzer R, Carmeli C, Chadeau-Hyam M, Stringhini S; Lifepath Consortium.

Cardiovasc Res. 2019 Nov 22. pii: cvz267. doi: 10.1093/cvr/cvz267. [Epub ahead of print].

Bone formation and resorption markers at 7 years of age: Relations with growth and bone mineralization

Monjardino T, Silva P, Amaro J, Carvalho O, Guimarães JT, Santos AC, Lucas R.

PLoS One. 2019 Aug 22;14(8):e0219423. doi: 10.1371/journal.pone.0219423. eCollection 2019.

Effect of problematic eating behaviors on the quality of food at 7 years of age.  

Pinto A, Costa S, Lopes C, Oliveira A.

Acta Portuguesa de Nutrição (APN) 2016; 40-41.

How do eating behaviors and physical activity in childhood evolve and aggregate?

Magalhães V, Vilela S, Oliveira A, Lopes C.

Acta Portuguesa de Nutrição (APN) 2016; 37.

Association of eating behaviors with the body mass index of children at 7 years of age  

Costa S, Pinto A, Lopes C, Oliveira A.

Acta Portuguesa de Nutrição (APN) 2016; 38.

Association of protein intake in preschool age with body mass index and serum insulin at 7 years of age

Durão C, Oliveira A, Santos AC, Guerra A, Barros H, Lopes C.

Acta Portuguesa de Nutrição (APN) 2016; 37.

Early life characteristics of appetite-related eating behaviors in 7 years-old children

Albuquerque G, Severo M, Oliveira A.

Acta Portuguesa de Nutrição (APN) 2016; 40.

The effect of parental child-feeding practices at 4 years old on child’s eating behaviors 3 years later

Afonso L, Santos S, Severo M, Lopes C, Oliveira A.

Acta Portuguesa de Nutrição (APN) 2016; 37-38.

Preschool age eating patterns and obesity at age 7

Durão C, Severo M, Oliveira A, Moreira P, Guerra A, Barros H, Lopes C. 

Acta Portuguesa de Nutrição (APN) 2015;36:37.

Children’s dietary patterns at 4 years: are they associated with appetite-related eating behaviours at 7 years old?

Albuquerque G, Lopes A, Durão C, Severo M, Oliveira A. 

Acta Portuguesa de Nutrição (APN) 2015; 35-36.

Geração XXI. XVI Semana de Ciências da Nutrição AEFCNAUP.

Pinto E.

2006. Porto, Portugal.

Alimentação antes e durante a gravidez: quais as diferenças?. IV Portuguese Congress of Epidemiology.

Pinto E, Lopes C, Barros H.

2006. Cascais, Portugal.

Social and behavioral determinants of HIV screening during pregnancy.

Quintas E, Correia S, Barros H.

135th American Association of Public Healt. 2007. Washington DC, USA.

Comparação de três métodos de quantificação da ingestão de ácidos gordos, durante a gravidez. V Portuguese Congress of Epidemiology.

Pinto E, Barros H.

2007. Lisboa, Portugal.

Comparação de diferentes métodos de avaliar a ingestão de folato durante a gravidez.

Pinto E, Lopes C, Severo M, Rodrigues T, Barros H.

VI Portuguese Congress of Epidemiology. 2008. Porto, Portugal.

Body image self-perception before pregnancy and adequacy of gestational weight gain.

Pinto E, Barros H.

XVIII IEA World Congress of Epidemiology. 2008. Porto Alegre, Brazil.

Prevalence of hypertension, dyslipidemia and diabetes mellitus in Portuguese young women, before pregnancy, 2005-2006.

Alves E, Azevedo A.

16th European Conference on Public Health. 2008. Lisbon, Portugal.

Newborns of medical assisted reproduction: are they different?

Vasconcellos G, Correia S, Calejo L, Rodrigues M, Guimarães H.

17th Neonatal Workshop on Neonatology. 2009. Vila do Conde, Portugal.

Prevalence of hypertension, dyslipidemia and diabetes mellitus in Portuguese young women, before pregnancy, 2005-2006.

Alves E, Azevedo A.

VI Portuguese Congress of Epidemiology. 2008. Porto, Portugal.

 
Validity and reproducibility of a semi-quantitative food frequency questionnaire for use among Portuguese pregnant women

Pinto E, Severo M, Correia S, Santos-Silva I, Lopes C, Barros H.

VI Portuguese Congress of Epidemiology. 2008. Porto, Portugal.

Intake of horticultural products in the preconceptional period and adequacy of micronutrients in Portuguese women

Pinto E, Barros H.

II National Congress Of Public Health. 2010. Porto, Portugal.

The effect of telephone sampling methods in prevalence estimates of health-related factors in Portuguese young adults

Correia S, Lunet N, Barros H.

XVIII IEA World Congress of Epidemiology. 2008. Porto Alegre, Brazil.

Generation XXI - The first Portuguese Birth Cohort

Correia S.

ENRIECO 1st meeting. 2009. Barcelona, Spain.

Maternal diet throughout pregnancy and fetal growth trajectories

Pinto E, Severo M, Cunha A, a Cunha, De Stavola B, Santos Silva I, Barros H.

European Congress of Epidemiology. 2009. Warsaw, Poland.

Low birth weight and other vascular-related outcomes of pregnancy and socioeconomic factors in mothers of a Portuguese birth cohort

Alves E, Azevedo A, Barros H.

European Congress of Epidemiology, . 2009. Warsaw, Poland.

Differences on risk of cesareansection after labour induction according different Portuguese hospitals

Teixeira C, Rodrigues T, Correia S, Barros H.

European Congress of Epidemiology. 2010. Florence, Italy.

Person, place and time contexts of growth and development of second generation migrant children in Portugal

Kana, Musa.

Programa Doutoral em Saúde Pública, Universidade do Porto. 2018.

Fetal Growth and Dietary Intake During Pregnancy: Results of Porto Birth Cohort

Pinto, Elisabete.

Doutoramento em Saúde Pública. Porto. 2010.

Cardiovascular Risk Profile in Mothers of a Portuguese Birth Cohort

Alves, Elisabete.

Doutoramento em Saúde Pública. Porto. 2012.

Cesarean - a role for culture, society and health care

Teixeira, Cristina.

Doutoramento em Saúde Pública. Universidade do Porto. 2013.

Prevalence and incidence of Helicobacter pylori infection in three Portuguese cohorts

Bastos, Joana Antunes de Lima.

Doutoramento em Saúde Pública. Universidade do Porto. 2013.

Reproductive and perinatal health in Portugal: social circumstances at the micro and macro level

Correia, Sofia.

Doutoramento em Saúde Pública. Universidade do Porto. 2014.

A influência dos determinantes de cárie dentária na prevalência da doença em crianças do Grande Porto

Coelho, Carina

Doutoramento em Medicina Dentária. Universidade do Porto. A decorrer

Sono ao longo da vida

Gonçalves, Marta

Doutoramento em Saúde Pública. Universidade do Porto. A decorrer

The effect of sugar-sweetened beverages on children’s appetitive behaviours: a prospective approach from the Generation XXI birth cohort

Costa, Daniela.

Mastr in Public Health. University of Porto. 2019.

Healthy eating patterns in childhood: tracking and its related factors  

Costa, Marta.

Master in Public Health. University of Porto. 2019.

Obesity-related dietary patterns in 7 years-old children from Generation XXI and their effects in cardiometabolic health later in life

Pinto, Andreia.

Master in Public Health. University of Porto. 2019.

Family and sociodemographic influences on the pain experience of 7-year-old children as reported by parents - a study of the Generation XXI birth cohort.

Guimarães, Susana.

Maste rin Education for Health. University of Porto. 2016.

Exploring the Usefulness of Peripheral and Central Dual Energy X-ray Absorptiometry Measures for Pediatric Research

Martins, Ana.

Master in Public Health, University of Porto. 2016.

 
Health care utilization in 4-year-old children - results of the Generation XXI cohort

Lobo, Susana.

Master in  Public Health, Universidade do Porto. 2016.

Acute respiratory tract infections in children at 24 months of age: cumulative incidence and risk factors

Vieira, Margarida Clara Rodrigues Mota.

Master in Epidemiology. University of Porto. 2010.

Social determinants in the choice of place of delivery and duration of breastfeeding in Generation XXI  

Pereira, Márcia.

Master in Public Health. Porto. 2010.

Awards and prizes
Sexo e obesidade modificam o impacto do sal na pressão arterial em crianças

Costa L, Cosme D, Nogueira-Silva L, Morato M, Sousa T, Moura C, Mota C, Guerra A, Albino-Teixeira A, Areias JC, Schaefer F, Lopes C, Caldas-Afonso A, Azevedo A.

Oral communication. Best work in other pediatric áreas. Pfizer Vacinas-SPP. 16º Congresso Nacional de Pediatria. Albufeira October 2015.

Social Trajectory and Body Image Satisfaction in Childbearing Women

Henriques A, Alves L, Alves E, Silva S, Barros H, Azevedo A.

Maternal and Child Health Journal. 2015 Jun;19(6):1237-44. Best 2014 publication, Associação Portuguesa de Epidemiologia. August 2015.

Dietary patterns at 4 years of age: are they associated with appetite-related eating behaviours in 7 year-old children?

Albuquerque G, Lopes c, Durão C, Severo M, Moreira P, Oliveira A.

II Ibero-American Congress of Epidemiology and Public Health. Santiago de Compostela, Spain, 2-4 September, 2015. 1st award “Patxi Català” SESPAS-EASP – best oral presentation.

Consumo alimentar e nutricional de crianças em idade pré-escolar: Resultados da coorte Geração 21

Carla Lopes, Andreia Oliveira, Lisa Afonso, Teresa Moreira, Catarina Durão, Milton Severo, Sofia Vilela, Elisabete Ramos, Henrique Barros

Instituto de Saúde Pública da Universidade do Porto 2014. (ISBN: 978-989-98867-4-2). 1st award Food & Nutrition Awards 2014 (APN/GCI) – research and development category.

Da mesa à horta: aprendo a gostar de fruta e vegetais: Um guia prático para pais e cuidadores de crianças em idade pré-escolar

Carla Lopes, Andreia Oliveira, Lisa Afonso, Catarina Durão, Pedro Moreira, Elisabete Pinto, Elisabete Ramos, Henrique Barros

Instituto de Saúde Pública da Universidade do Porto 2014. (ISBN: 978-989-98867-3-5). 2nd honorable mention, Food & Nutrition Awards 2014 (APN/GCI) – category mobilization initiative.

Identificação de padrões alimentares em crianças com 4 anos de idade

Durão C, Severo M, Oliveira A, Ramos E, Lopes C

Best oral presentation, XIII Congresso de Nutrição e Alimentação da Associação Portuguesa dos Nutricionistas. Porto, 22 May 2014.

Association between energy-dense food consumption at 2 years of age and diet quality at 4 years of age

Vilela S, Oliveira A, Ramos E, Moreira P, Barros H, Lopes C

Br J Nutr. 2014 Apr 14;111(7):1275-82. Best publication of 2013, Associação Portuguesa de Epidemiologia.

Association between energy-dense food consumption at 2 years of age and diet quality at 4 years of age

Vilela S, Oliveira A, Ramos E, Moreira P, Barros H, Lopes C.

Br J Nutr. 2013 Nov 14:1-8. DOI:http://dx.doi.org/10.1017/S0007114513003620. Associação Portuguesa de Epidemiologia, 2013. Best publication of research in epidemiology (population, clinical or translational)

Disciplina parental e saúde: um estudo na coorte Geração 21

Diogo Mendes, Isabel Moreira, Henrique Barros

3º Congresso sobre o Abuso e Negligência de Crianças. 2013. Porto, Portugal. Best oral presentation.

Perda de peso neonatal numa amostra portuguesa - coorte de nascimento Geração XXI

Maria João Fonseca, Milton Severo, Henrique Barros, Ana Cristina Santos

14º Congresso Nacional de Pediatria. 2013. Porto, Portugal. – Best work in general pediatrics.

 Early growth and the risk of childhood asthma: a meta-analysis of 1,000 European children

Sonnenschein-van der Voort AMM, Arends LR,  Jongste JC de, Annesi-Maesano I, Barros H, Basterrechea M, Bisgaard H, Chatzi L, Corpeleijn E, Correia S, Craig LC, et al.

European Respiratory Society Annual Meeting. 2013. Barcelona, Spain. Best Abstract in Paediatric Respiratory Epidemiology

Obesidade saudável em mulheres Portuguesas após a maternidade

Henriques A, Azevedo A, Barros H.

16º Congresso Português de Obesidade. Lisbon. November 2012. Best oral presentation in obesity and comorbidities.

Satisfação com a imagem corporal antes da gravidez e excesso de peso quatro anos após o parto

Henriques A, Alves E, Azevedo A, Barros H.

15º Congresso Português de Obesidade. Coimbra. November 2011. Best oral presentation in psychology.

Determinantes sociais do consumo de alimentos de elevada densidade energética em crianças de 2 anos

Sofia Vilela, Andreia Oliveira, Ana cristina Santos, Elisabete Pinto, Isabel Moreira, Carla Lopes

X Congresso de Nutrição e Alimentação & Congresso Ibero-Americano de Nutrição. 2011. Lisbon, Portugal. Best oral presentation.

Cigarette smoking cessation during pregnancy and sustainability 4 years after delivery

Alves E, Correia S, Azevedo A, Barros H.

Congresso Mundial de Epidemiologia. Edimburgo, 2011. Best panel presentation in “Global Problems”.

Prevalência e determinantes da infecção por helicobacter pylori no início da vida: resultados de uma coorte de nascimento portuguesa

Nuno Lunet

2011. Scientific Research award Dr.ª Maria Odette Ferreira-Santos.

Avaliação da ingestão alimentar em grávidas portuguesas

Elisabete Pinto, Carla Lopes, Milton Severo, Elisabete Ramos, Sofia Correia, Susana Cabral, Isabel dos Santos Silva, Henrique Barros

Nutrition Awards. 2011. Research Award in Nutrition Sciences.

Colaborations
Projects in collaboration with international institutions
Birthcohorts.net
CHICOS– Developing a Child Cohort Research Strategy for Europe
ENRIECO – Environmental Health Risks in European Birth Cohorts
EUCCONET – The European Child Cohort Network